raloxifene

Generic Name: raloxifene (oral) (ra LOX i feen)

Brand Names: Evista

What is raloxifene?

Raloxifene affects the cycle of bone formation and breakdown in the body, and reduces loss of bone tissue.

Raloxifene is used to treat or prevent osteoporosis in postmenopausal women. Raloxifene is also used to reduce the risk of invasive breast cancer in postmenopausal women who have osteoporosis or who are otherwise at risk of invasive breast cancer.

Raloxifene may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about raloxifene?

You should not use this medication if you are allergic to raloxifene, if you are pregnant or breast-feeding, or if you have ever had a blood clot. Although it is not likely that a postmenopausal woman would be pregnant, raloxifene can cause birth defects and should not be used during pregnancy. Tell your doctor right away if you become pregnant during treatment.

Before taking raloxifene, tell your doctor if you smoke or if you have coronary artery disease, heart disease, high blood pressure, liver or kidney disease, a history of stroke or TIA, high triglycerides, if you have not gone through menopause, or if you have had breast cancer in the past.

If you need to have any type of surgery or will be on bed rest, you will need to stop taking raloxifene for at least 72 hours before your surgery or before you plan to be immobile. Any doctor or surgeon who treats you should know that you are taking raloxifene.

Avoid sitting still for long periods of time during travel while you are taking raloxifene.

What should I discuss with my healthcare provider before taking raloxifene?

You should not use this medication if you are allergic to raloxifene, if you are pregnant or breast-feeding, or if you have ever had a blood clot.

Before taking this medication, tell your doctor if you smoke or if you have:

• 
  

  coronary artery disease (atherosclerosis);

  
  


• 
  

  heart disease;

  
  


• 
  

  high blood pressure;

  
  


• liver or kidney disease;


• 
  

  a history of stroke or TIA ("mini-stroke");

  
  


• 
  

  high triglycerides (often occurs with high cholesterol);

  
  


• 
  

  if you have not gone through menopause; or

  
  


• 
  

  if you have had breast cancer in the past.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests to safely take raloxifene.

FDA pregnancy category X. Although it is not likely that a postmenopausal woman would be pregnant, raloxifene can cause birth defects and should not be used during pregnancy. Tell your doctor right away if you become pregnant during treatment. It is not known whether raloxifene passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take raloxifene?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Raloxifene can be taken with or without food.

You may take raloxifene at any time of the day, but try to take it at the same time each day.

If your raloxifene tablets are packaged on blister cards, take the medication as follows:

• 
  

  Each blister card contains 15 tablets labeled with a different day of the week. The first tablet you use should be labeled with the day of the week your doctor has instructed you to start taking raloxifene.

  
  


• 
  

  If you have refilled your prescription and are starting a new blister pack, take the tablet that is labeled one day after you took your last dose.

  
  


• 
  

  Keep taking the medication one tablet per day, unless your doctor has told you otherwise.

  
  


• 
  

  Try to take the medication at the same time each day.

  
  


• 
  

  The tablet in the center of the blister card should be the last tablet you take before starting a new card.

  
  

If you need to have any type of surgery or will be on bed rest, you will need to stop taking raloxifene for at least 72 hours before your surgery or before you plan to be immobile. Any doctor or surgeon who treats you should know that you are taking raloxifene.

Raloxifene is only part of a complete program of treatment that may also include diet, exercise, calcium or vitamin D supplements, and weight control. Follow your diet, medication, and exercise routines very closely.

Store raloxifene at room temperature away from moisture and heat.

See also: Raloxifene dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek medical attention if you think you have used too much of this medicine.

Overdose symptoms may include leg cramps and dizziness.

What should I avoid while taking raloxifene?

If you take calcium supplements, do not take more than your doctor has prescribed. Taking more calcium than recommended will not provide extra protection for your bones, and may cause serious side effects including kidney stones.

Avoid sitting still for long periods of time during travel while you are taking raloxifene.

Raloxifene side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  sudden numbness or weakness, especially on one side of the body;

  
  


• 
  

  sudden headache, confusion, problems with vision, speech, or balance;

  
  


• 
  

  chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;

  
  


• 
  

  pain or swelling in one or both legs;

  
  


• 
  

  swelling in your hands or feet;

  
  


• 
  

  fever, chills, sore throat, body aches, flu symptoms;

  
  


• 
  

  unusual vaginal bleeding;

  
  


• 
  

  breast pain, tenderness, or lump;

  
  


• 
  

  pain or burning when you urinate; or

  
  


• 
  

  severe pain in your lower back.

  
  

Less serious side effects may include:

• 
  

  hot flashes;

  
  


• 
  

  headache, dizziness, spinning sensation;

  
  


• 
  

  leg pain;

  
  


• 
  

  joint pain;

  
  


• 
  

  increased sweating;

  
  


• 
  

  nausea, vomiting, stomach pain; or

  
  


• 
  

  runny or stuffy nose.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Raloxifene Dosing Information

Usual Adult Dose for Osteoporosis:

1 tablet (60 mg) orally once a day

Usual Adult Dose for Prevention of Osteoporosis:

1 tablet (60 mg) orally once a day

Usual Adult Dose for Prevention of Breast Cancer:

1 tablet (60 mg) orally once a day

What other drugs will affect raloxifene?

Before taking raloxifene, talk to your doctor if you are taking any of the following medicines:

• 
  

  cholestyramine (Questran, Prevalite);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin); or

  
  


• 
  

  diazepam (Valium);

  
  


• 
  

  diazoxide (Proglycem); or

  
  


• 
  

  birth control pills or hormone replacement therapy.

  
  

This list is not complete and there may be other drugs that can interact with raloxifene. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More raloxifene resources

• Raloxifene Side Effects (in more detail)
• Raloxifene Dosage
• Raloxifene Use in Pregnancy & Breastfeeding
• Raloxifene Drug Interactions
• Raloxifene Support Group
• 2 Reviews for Raloxifene - Add your own review/rating

• raloxifene Advanced Consumer (Micromedex) - Includes Dosage Information


• Raloxifene MedFacts Consumer Leaflet (Wolters Kluwer)


• Evista Prescribing Information (FDA)


• Evista Consumer Overview


• Evista Monograph (AHFS DI)

Compare raloxifene with other medications

• Breast Cancer, Prevention
• Osteoporosis
• Prevention of Osteoporosis

Where can I get more information?

• Your pharmacist can provide more information about raloxifene.

See also: raloxifene side effects (in more detail)

Remeron

Generic Name: mirtazapine (Oral route)

mir-TAZ-a-peen

Oral route(Tablet;Tablet, Disintegrating)

Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder (MDD) and other psychiatric disorders in short-term studies. Short term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. This risk must be balanced with the clinical need. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Not approved for use in pediatric patients .

Commonly used brand name(s)

In the U.S.

• Remeron


• Remeron Soltab

In Canada

• Remeron RD

Available Dosage Forms:

• Tablet, Disintegrating


• Tablet

Therapeutic Class: Antidepressant

Pharmacologic Class: Antidepressant, Tetracyclic

Uses For Remeron

Mirtazapine is used to treat symptoms of depression. It works in the central nervous system (CNS) to make certain chemicals in the brain stronger. Mirtazapine belongs to a group of medicines called tetracyclic antidepressants.

This medicine is available only with your doctor's prescription.

Before Using Remeron

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

No information is available on the relationship of age to the effects of mirtazapine in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of mirtazapine in the elderly. However, elderly patients are more likely to have confusion or unusual drowsiness and age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving mirtazapine.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Isocarboxazid


• Linezolid


• Methylene Blue


• Metoclopramide


• Rasagiline


• Selegiline


• Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Clonidine


• Fluoxetine


• Fluvoxamine


• Olanzapine


• Procarbazine


• Tramadol


• Venlafaxine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Diazepam

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Angina (severe chest pain), history of or


• Blood vessel disease or circulation problems or


• Dehydration or


• Heart attack, history of or


• Heart disease or


• Hypotension (low blood pressure) or


• Hypovolemia (low blood volume) or


• Stroke, history of—May cause side effects to become worse.

• Hypercholesterolemia (high cholesterol in the blood) or


• Mania or hypomania, history of or


• Seizures, history of—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

• Phenylketonuria (PKU)—The orally disintegrating tablet contains aspartame, which can make this condition worse.

Proper Use of mirtazapine

This section provides information on the proper use of a number of products that contain mirtazapine. It may not be specific to Remeron. Please read with care.

Take this medicine exactly as directed by your doctor in order to improve your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Mirtazapine may be taken with or without food, on a full or empty stomach. If your doctor tells you to take it a certain way, follow your doctor's instructions.

To use the orally disintegrating tablet:

• Make sure your hands are dry before you handle the tablet.


• Do not open the blister pack that contains the tablet until you are ready to take it.


• Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.


• Immediately place the tablet on top of the tongue. Do not break or split the tablet.


• The tablet will dissolve in seconds, and you may swallow it with your saliva. You do not need to drink water or other liquids to swallow the tablet.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (orally disintegrating tablets and tablets):
  
  • For depression:
    
    • Adults—At first, 15 milligrams (mg) once a day, preferably in the evening just before sleep. Your doctor may adjust your dose if needed. However, the dose is usually not more than 45 mg per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Remeron

It is very important that your doctor check your progress at regular visits to see if the medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.

For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts of hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or getting worse quickly. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.

This medicine may add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are taking this medicine.

This medicine can temporarily lower the number of white blood cells in your blood, increasing your chance of getting an infection. If you can, avoid people with infections. Stop using this medicine and check with your doctor right away if you think you are getting an infection or if you have a fever or chills, sore throat, sores in the mouth, lower back or side pain, or painful or difficult urination.

This medicine may increase your weight. Your doctor may need to check your weight on a regular basis while you are using this medicine.

Mirtazapine may cause drowsiness, trouble with thinking, or trouble with controlling body movements. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires you to be alert, well-coordinated, and able to think well.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

This medicine may cause dryness of the mouth. For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth feels dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Remeron Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Decreased or increased movement


• mood or mental changes, including abnormal thinking, agitation, anxiety, confusion, and feelings of not caring


• shortness of breath


• skin rash


• swelling

Rare

• Change in menstrual cycle (periods)


• convulsions (seizures)


• decreased sexual ability


• menstrual pain


• mood or mental changes, including anger, feelings of being outside the body, hallucinations (seeing, hearing, or feeling things that are not there), mood swings, and unusual excitement


• mouth sores


• sore throat, chills, or fever

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Constipation


• dizziness


• drowsiness


• dry mouth


• increased appetite


• weight gain

Less common

• Abdominal or stomach pain


• abnormal dreams


• back pain


• dizziness or fainting when getting up suddenly from a lying or sitting position


• increased need to urinate


• increased sensitivity to touch


• increased thirst


• low blood pressure


• muscle pain


• nausea


• sense of constant movement of self or surroundings


• trembling or shaking


• vomiting


• weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Remeron side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Remeron resources

• Remeron Side Effects (in more detail)
• Remeron Use in Pregnancy & Breastfeeding
• Drug Images
• Remeron Drug Interactions
• Remeron Support Group
• 82 Reviews for Remeron - Add your own review/rating

• Remeron Monograph (AHFS DI)


• Remeron Prescribing Information (FDA)


• Remeron Consumer Overview


• Remeron MedFacts Consumer Leaflet (Wolters Kluwer)


• Mirtazapine Professional Patient Advice (Wolters Kluwer)


• Remeron SolTab Orally Disintegrating Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Remeron with other medications

• Anxiety
• Depression
• Hot Flashes
• Insomnia

Ranexa

Pronunciation: ra-NOE-la-zeen
Generic Name: Ranolazine
Brand Name: Ranexa

Ranexa is used for:

Treating chronic chest pain (angina). It may be used alone or in combination with other medicines.

Ranexa is an antianginal medicine. Exactly how it works is not known.

Do NOT use Ranexa if:

• you are allergic to any ingredient in Ranexa


• you have liver cirrhosis


• you are taking certain azole antifungals (eg, itraconazole, ketoconazole), barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), certain macrolide antibiotics (eg, clarithromycin), nefazodone, certain protease inhibitors (eg, indinavir, nelfinavir, ritonavir, saquinavir), a rifamycin (eg, rifampin), St. John's wort, or telithromycin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ranexa:

Some medical conditions may interact with Ranexa. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of liver problems, kidney problems or if you are on dialysis, or have diabetes


• if you have a personal or family history of irregular heartbeat (eg, prolonged QTc interval, congenital long QT syndrome), abnormal heart function tests, or low blood potassium levels


• if you take certain antipsychotics (eg, thioridazine, ziprasidone) or antiarrhythmics (eg, amiodarone, dofetilide, quinidine, sotalol), or any other medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Ranexa. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aprepitant, azole antifungals (eg, itraconazole, ketoconazole, fluconazole), cyclosporine, diltiazem, macrolide antibiotics (eg, clarithromycin, erythromycin), nefazodone, protease inhibitors (eg, boceprevir, ritonavir), telithromycin, or verapamil because they may increase the risk of Ranexa's side effects


• Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), rifamycins (eg, rifampin), or St. John's wort because they may decrease Ranexa's effectiveness


• Digoxin, lovastatin, simvastatin, sirolimus, tacrolimus, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Ranexa

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ranexa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ranexa:

Use Ranexa as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Ranexa by mouth with or without food.


• Swallow Ranexa whole. Do not break, crush, or chew before swallowing.


• Check with your doctor before you eat grapefruit or drink grapefruit juice while you are taking Ranexa.


• If you miss a dose of Ranexa, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ranexa.

Important safety information:

• Ranexa may cause dizziness, light-headedness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Ranexa with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Ranexa may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.


• Do NOT take more than the recommended dose without checking with your doctor.


• Ranexa is not effective in treating an angina attack. Talk to your doctor about how to treat an angina attack.


• Lab tests, including heart function, may be performed while you use Ranexa. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Ranexa with caution in the ELDERLY; they may be more sensitive to its effects.


• Ranexa should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ranexa while you are pregnant. It is not known if Ranexa is found in breast milk. Do not breast-feed while taking Ranexa.

Possible side effects of Ranexa:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; headache; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); blood in the urine; blurred vision; change in the amount of urine produced; chest pain; confusion; decreased sense of touch; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; numbness, burning, prickling, or tingling of the skin; severe or persistent dizziness, light-headedness, or weakness; shortness of breath; swelling of the hands or feet; tremor; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Ranexa side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include confusion; double vision; fainting; numbness, burning, prickling, or tingling of the skin; severe or persistent dizziness, nausea, or vomiting.

Proper storage of Ranexa:

Store Ranexa at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ranexa out of the reach of children and away from pets.

General information:

• If you have any questions about Ranexa, please talk with your doctor, pharmacist, or other health care provider.


• Ranexa is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ranexa. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ranexa resources

• Ranexa Side Effects (in more detail)
• Ranexa Use in Pregnancy & Breastfeeding
• Drug Images
• Ranexa Drug Interactions
• Ranexa Support Group
• 11 Reviews for Ranexa - Add your own review/rating

• Ranexa Prescribing Information (FDA)


• Ranexa Consumer Overview


• Ranexa Monograph (AHFS DI)


• Ranexa Advanced Consumer (Micromedex) - Includes Dosage Information


• Ranolazine Professional Patient Advice (Wolters Kluwer)

Compare Ranexa with other medications

• Angina

Rescon-GG Liquid

Pronunciation: gwye-FEN-e-sin/fen-il-EF-rin
Generic Name: Guaifenesin/Phenylephrine
Brand Name: Examples include Entex and Rescon-GG

Rescon-GG Liquid is used for:

Relieving symptoms of congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Rescon-GG Liquid is a decongestant and expectorant combination. It works by constricting blood vessels and shrinking swollen and congested nasal tissues (mucous membranes) and by thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.

Do NOT use Rescon-GG Liquid if:

• you are allergic to any ingredient in Rescon-GG Liquid


• you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems


• you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Rescon-GG Liquid:

Some medical conditions may interact with Rescon-GG Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a fast, slow, or irregular heartbeat


• if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate, seizures, or an overactive thyroid


• if you have chronic cough

Some MEDICINES MAY INTERACT with Rescon-GG Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Rescon-GG Liquid's side effects


• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased


• Bromocriptine because its side effects may be increased by Rescon-GG Liquid


• Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because its effectiveness may be decreased by Rescon-GG Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Rescon-GG Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Rescon-GG Liquid:

Use Rescon-GG Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Rescon-GG Liquid by mouth with or without food.


• Take Rescon-GG Liquid with a full glass of water (8 oz/240 mL) unless your doctor directs otherwise.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of Rescon-GG Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Rescon-GG Liquid.

Important safety information:

• Rescon-GG Liquid may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Rescon-GG Liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do not take diet or appetite control medicines while you are taking Rescon-GG Liquid without checking with you doctor.


• Do NOT take more than the recommended dose without checking with your doctor.


• If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.


• Rescon-GG Liquid may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Rescon-GG Liquid.


• Tell your doctor or dentist that you take Rescon-GG Liquid before you receive any medical or dental care, emergency care, or surgery.


• Use Rescon-GG Liquid with caution in the ELDERLY; they may be more sensitive to its effects.


• Caution is advised when using Rescon-GG Liquid in CHILDREN; they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Rescon-GG Liquid while you are pregnant. It is not known if Rescon-GG Liquid is found in breast milk. Do not breast-feed while taking Rescon-GG Liquid.

Possible side effects of Rescon-GG Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Rescon-GG side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Rescon-GG Liquid:

Store Rescon-GG Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Rescon-GG Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about Rescon-GG Liquid, please talk with your doctor, pharmacist, or other health care provider.


• Rescon-GG Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Rescon-GG Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Rescon-GG resources

• Rescon-GG Side Effects (in more detail)
• Rescon-GG Use in Pregnancy & Breastfeeding
• Rescon-GG Drug Interactions
• Rescon-GG Support Group
• 0 Reviews for Rescon-GG - Add your own review/rating

Compare Rescon-GG with other medications

• Cough and Nasal Congestion
• Sinus Symptoms

ReliOn/Novolin R

Generic Name: insulin regular (IN soo lin REG yoo lar)

Brand Names: HumuLIN R, NovoLIN R, NovoLIN R Innolet, NovoLIN R PenFill, ReliOn/NovoLIN R

What is ReliOn/Novolin R (insulin regular)?

Insulin is a hormone that is produced in the body. It works by lowering levels of glucose (sugar) in the blood. Insulin regular is a short-acting form of insulin.

Insulin regular is used to treat diabetes.

Insulin regular may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about ReliOn/Novolin R (insulin regular)?

Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.

Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your insulin dose.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another.

Insulin is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Do not change the brand of insulin or syringe you are using without first talking to your doctor or pharmacist. Some brands of insulin regular and syringes are interchangeable, while others are not. Your doctor and/or pharmacist know which brands can be substituted for one another.

What should I discuss with my healthcare provider before using ReliOn/Novolin R (insulin regular)?

Do not use this medication if you are allergic to insulin, or if you are having an episode of hypoglycemia (low blood sugar).

To make sure you can safely use insulin, tell your doctor if you have liver or kidney disease.

Tell your doctor about all other medications you use, including any oral (by mouth) diabetes medications.

Insulin regular is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

FDA pregnancy category B. Insulin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether insulin regular passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ReliOn/Novolin R (insulin regular)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Visit your doctor regularly.

Insulin regular is injected under the skin. You may be shown how to use injections at home. Do not self inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

Choose a different place in your injection skin area each time you use this medication. Do not inject into the same place two times in a row.

Insulin regular should look as clear as water. Do not use the medication if has changed colors, looks cloudy, or has particles in it. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Some types of insulin needles can be used more than once. But reusing needles increases your risk of infection. Used needles must be properly cleaned and inspected for bending or breakage. Ask your doctor or pharmacist whether you can reuse your insulin needles.

Never share an injection pen or cartridge with another person. Sharing injection pens or cartridges can allow disease such as hepatitis or HIV to pass from one person to another. Know the signs of low blood sugar (hypoglycemia) and how to recognize them: headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating.

Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.

Also watch for signs of blood sugar that is too high (hyperglycemia). These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

Check your blood sugar carefully during a time of stress or illness, if you travel, exercise more than usual, drink alcohol, or skip meals. These things can affect your glucose levels and your dose needs may also change.

Your doctor may want you to stop taking insulin for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency.

Ask your doctor how to adjust your insulin dose if needed. Do not change your medication dose or schedule without your doctor's advice.

If your doctor changes your brand, strength, or type of insulin, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of insulin you receive at the pharmacy.

Carry an ID card or wear a medical alert bracelet stating that you have diabetes, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are diabetic.

Insulin is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels.

Storing unopened vials and cartridges: Keep in the carton and store in a refrigerator, protected from light. Unopened vials may also be stored at room temperature, away from heat and bright light.

Storing after your first use: Keep the "in-use" vials or cartridges at room temperature.

Do not freeze insulin regular, and throw away the medication if it has become frozen.

Throw away any insulin not used before the expiration date on the medicine label.

What happens if I miss a dose?

Since insulin regular is used before meals or snacks, you may not be on a timed dosing schedule. Whenever you use insulin regular, be sure to eat a meal or snack within 15 to 30 minutes. Do not use extra insulin to make up a missed dose.

It is important to keep insulin regular on hand at all times. Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An insulin overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).

What should I avoid while using ReliOn/Novolin R (insulin regular)?

Do not change the brand of insulin regular or syringe you are using without first talking to your doctor or pharmacist. Avoid drinking alcohol. Your blood sugar may become dangerously low if you drink alcohol while using insulin regular.

ReliOn/Novolin R (insulin regular) side effects

Get emergency medical help if you have any of these signs of insulin allergy: itching skin rash over the entire body, wheezing, trouble breathing, fast heart rate, sweating, or feeling like you might pass out.

Hypoglycemia, or low blood sugar, is the most common side effect of insulin. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

Tell your doctor if you have itching, swelling, redness, or thickening of the skin where you inject insulin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ReliOn/Novolin R (insulin regular)?

Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:

• 
  

  albuterol (Proventil, Ventolin);

  
  


• 
  

  clonidine (Catapres);

  
  


• 
  

  reserpine; or

  
  


• 
  

  beta-blockers such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

  
  

These lists are not complete and there are many other medicines that can increase or decrease the effects of insulin on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription, over the counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More ReliOn/Novolin R resources

• ReliOn/Novolin R Side Effects (in more detail)
• ReliOn/Novolin R Use in Pregnancy & Breastfeeding
• ReliOn/Novolin R Drug Interactions
• ReliOn/Novolin R Support Group
• 0 Reviews for ReliOn/Novolin R - Add your own review/rating

• Humulin R MedFacts Consumer Leaflet (Wolters Kluwer)


• Humulin R Prescribing Information (FDA)


• Humulin R (Concentrated) MedFacts Consumer Leaflet (Wolters Kluwer)


• Novolin R Prescribing Information (FDA)

Compare ReliOn/Novolin R with other medications

• Diabetes, Type 1
• Diabetes, Type 2
• Diabetic Ketoacidosis
• Gestational Diabetes
• Growth Hormone Reserve Test
• Hyperkalemia
• Insulin Resistance Syndrome
• Nonketotic Hyperosmolar Syndrome

Where can I get more information?

• Your pharmacist can provide more information about insulin regular.

See also: ReliOn/Novolin R side effects (in more detail)

Respi-TANN

Generic Name: carbetapentane and pseudoephedrine (kar BAY ta PEN tane and SOO doe ee FED rin)

Brand Names: Allres Pd, Carb Pseudo-Tan, Corzall, Pseudacarb, Re-Tann, Respi-TANN, Respi-Tann Pd

What is Respi-TANN (carbetapentane and pseudoephedrine)?

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Carbetapentane is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

The combination of carbetapentane and pseudoephedrine is used to treat cough and nasal and sinus congestion caused by the common cold, flu, or bronchitis.

Carbetapentane and pseudoephedrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Respi-TANN (carbetapentane and pseudoephedrine)?

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Ask a doctor or pharmacist before using any cough, cold, or allergy medicine. Many combination medicines available over the counter may contain similar drug ingredients. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains a decongestant or cough suppressant. Do not take a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

What should I discuss with my healthcare provider before taking Respi-TANN (carbetapentane and pseudoephedrine)?

Do not take a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects. You should not take this medication if you are allergic to carbetapentane or pseudoephedrine, or if you have severe or untreated high blood pressure or coronary artery disease.

To make sure you can safely take carbetapentane and pseudoephedrine, tell your doctor if you have any of these other conditions:

• 
  

  heart disease or high blood pressure;

  
  


• 
  

  a seizure disorder;

  
  


• 
  

  glaucoma;

  
  


• 
  

  an enlarged prostate or problems with urination;

  
  


• 
  

  diabetes; or

  
  


• 
  

  a thyroid disorder.

  
  

FDA pregnancy category C. It is not known whether carbetapentane and pseudoephedrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Carbetapentane and pseudoephedrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Respi-TANN (carbetapentane and pseudoephedrine)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

The chewable tablet must be chewed before you swallow it.

Do not take carbetapentane and pseudoephedrine for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need surgery, tell the surgeon ahead of time if you have taken a cough or cold medicine within the past few days.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since cough or cold medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Respi-TANN (carbetapentane and pseudoephedrine)?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of carbetapentane and pseudoephedrine.

Avoid taking this medication if you also take diet pills, caffeine pills, or other stimulants (such as ADHD medications). Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Ask a doctor or pharmacist before using any cough, cold, or allergy medicine. Many combination medicines available over the counter may contain similar drug ingredients. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains a decongestant or cough suppressant.

Respi-TANN (carbetapentane and pseudoephedrine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking this medication and call your doctor at once if you have a serious side effect such as:

• 
  

  fast, pounding, or uneven heartbeat;

  
  


• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  confusion, hallucinations;

  
  


• 
  

  slow, shallow breathing;

  
  


• 
  

  easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, ringing in your ears, anxiety, confusion, chest pain, trouble breathing, uneven heart rate, seizure).

  
  

Less serious side effects may include:

• 
  

  loss of appetite, upset stomach;

  
  


• 
  

  warmth, redness, or tingling under your skin;

  
  


• 
  

  feeling excited or restless;

  
  


• 
  

  sleep problems (insomnia); or

  
  


• 
  

  mild skin rash or itching.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Respi-TANN (carbetapentane and pseudoephedrine)?

Tell your doctor about all other medicines you use, especially:

• 
  

  celecoxib (Celebrex);

  
  


• 
  

  cinacalcet (Sensipar);

  
  


• 
  

  darifenacin (Enablex);

  
  


• 
  

  imatinib (Gleevec);

  
  


• 
  

  quinidine (Quin-G);

  
  


• 
  

  ranolazine (Ranexa)

  
  


• 
  

  ritonavir (Norvir, Kaletra);

  
  


• 
  

  sibutramine (Meridia);

  
  


• 
  

  terbinafine (Lamisil);

  
  


• 
  

  medicines to treat high blood pressure;

  
  


• 
  

  an antidepressant such as amitriptyline (Elavil, Vanatrip), bupropion (Wellbutrin, Zyban), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), paroxetine (Paxil), sertraline (Zoloft), and others; or

  
  


• 
  

  a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

  
  

This list is not complete and other drugs may interact with carbetapentane and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Respi-TANN resources

• Respi-TANN Side Effects (in more detail)
• Respi-TANN Use in Pregnancy & Breastfeeding
• Respi-TANN Drug Interactions
• Respi-TANN Support Group
• 0 Reviews for Respi-TANN - Add your own review/rating

• Corzall Liquid MedFacts Consumer Leaflet (Wolters Kluwer)


• Corzall Prescribing Information (FDA)


• Respi-Tann Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Respi-TANN with other medications

• Cough and Nasal Congestion

Where can I get more information?

• Your pharmacist can provide more information about carbetapentane and pseudoephedrine.

See also: Respi-TANN side effects (in more detail)

Rebif

Generic Name: interferon beta-1a (in ter FEAR on BAY ta)

Brand Names: Avonex, Avonex Prefilled Syringe, Rebif

What is interferon beta-1a?

Interferon beta-1a is made from human proteins. Interferons help the body fight viral infections.

Interferon beta-1a is used to treat relapsing multiple sclerosis (MS). This medication will not cure MS, it will only decrease the frequency of relapse symptoms.

Interferon beta-1a may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about interferon beta-1a?

This medication may be harmful to an unborn baby, or may cause a miscarriage. Do not use interferon beta-1a if you are pregnant. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Before using interferon beta-1a, tell your doctor if you are allergic to any drugs, or if you have liver disease, a thyroid disorder, epilepsy or other seizure disorder, heart disease, chest pain (angina), congestive heart failure, a heart rhythm disorder, or a history of depression or suicidal behavior.

Some patients using interferon medications have become very depressed or had thoughts of suicide. Stop using interferon beta-1a if you have symptoms of depression (sadness, crying, loss of interest in things you once liked) or if you have any thoughts of hurting yourself. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

To be sure this medication is not causing harmful effects, your blood may need to be tested often. Your liver or thyroid function may also need to be tested. Visit your doctor regularly.

What should I discuss with my healthcare provider before using interferon beta-1a?

Do not use this medication if you are allergic to interferons or human albumin. Some patients using interferon medications have become very depressed or had thoughts of suicide. Stop using interferon beta-1a if you have symptoms of depression (sadness, crying, loss of interest in things you once liked) or if you have any thoughts of hurting yourself.

If you have any of these other conditions, you may need a dose adjustment or special tests:

• 
  

  liver disease;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  heart disease, chest pain (angina), congestive heart failure, or a heart rhythm disorder;

  
  


• 
  

  a thyroid disorder; or

  
  


• 
  

  a history of depression or suicidal behavior.

  
  

FDA pregnancy category C. This medication may be harmful to an unborn baby, or may cause a miscarriage. Do not use interferon beta-1a if you are pregnant. Tell your doctor if you become pregnant during treatment. It is not known whether interferon beta-1a passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Avonex powder contains albumin, but the Avonex prefilled syringe does not. Albumin comes from human plasma (part of the blood) and may contain viruses and other infectious agents that can cause disease. Although donated human plasma is screened, tested, and treated to reduce the risk of it containing anything that could cause disease, there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

How should I use interferon beta-1a?

Avonex is injected into a muscle. It is usually given once weekly at bedtime, on the same day each week (such as every Monday). Follow your doctor's instructions.

Rebif is injected under the skin. It is usually given 3 times per week (such as Monday, Wednesday, and Friday) at the same time on each dosing day. Follow your doctor's instructions.

You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Use a different place on your body each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

The powder form of Avonex must be mixed with a liquid (diluent) in the medicine vial. Gently swirl but do not shake the vial after mixing the medicine. The mixture should be clear or light yellow. Do not use the mixture if it has changed colors or has any particles in it. Mix a new dose or call your doctor for a new prescription.

Do not draw your dose into a syringe until you are ready to give yourself an injection.

Each prefilled syringe or single use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left after injecting your dose.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Interferon beta-1 can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Your liver or thyroid function may also need to be tested. Visit your doctor regularly.

Store interferon beta-1a in a refrigerator. Do not freeze. You may take the Avonex prefilled syringe out of the refrigerator and allow it to reach room temperature before giving the injection. Do not heat the medicine before using. Interferon beta-1a may be kept at room temperature for short periods if protected from light. Avonex powder or Rebif prefilled syringes can be stored at room temperature for up to 30 days. Avonex prefilled syringes can be stored at room temperature for only 7 days. After mixing Avonex powder with a diluent, store in the refrigerator and use it within 6 hours.

Throw away any interferon beta-1a that has become frozen or has been exposed to light or high heat.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of this medication. Your injections should be at least 48 hours apart. Do not use interferon beta-1a injections 2 days in a row.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using interferon beta-1a?

Avoid drinking alcohol. It may increase your risk of liver damage.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Interferon beta-1a side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

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  depressed mood, anxiety, trouble sleeping, restlessness, or thoughts of suicide or hurting yourself;

  
  


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  easy bruising or bleeding, weakness;

  
  


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  seizure (convulsions);

  
  


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  numbness or tingling in your hands or feet;

  
  


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  pain or burning when you urinate;

  
  


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  pain, swelling, or skin changes where the injection was given;

  
  


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  fever, chills, body aches, flu symptoms; or

  
  


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  nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

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  headache, dizziness;

  
  


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  stomach pain; or

  
  


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  runny or stuffy nose.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect interferon beta-1a?

Interferon beta-1a can harm your liver. This effect is increased when you also use other medicines harmful to the liver. Many other drugs (including some over-the-counter medicines) can be harmful to the liver, such as:

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  acetaminophen (Tylenol);

  
  


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  cancer medications;

  
  


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  tuberculosis medications;

  
  


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  birth control pills or hormone replacement therapy;

  
  


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  methotrexate (Rheumatrex, Trexall);

  
  


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  arthritis medications such as auranofin (Ridaura);

  
  


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  an antibiotic;

  
  


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  HIV/AIDS medications;

  
  


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  cholesterol medications such atorvastatin (Lipitor), simvastatin (Zocor), and others;

  
  


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  an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), lisinopril (Prinivil, Zestril), and others;

  
  


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  an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), indomethacin (Indocin), and others; or

  
  


• 
  

  seizure medications such as carbamazepine (Carbatrol, Tegretol), phenytoin (Dilantin), or valproic acid (Depakene).

  
  

This list is not complete and other drugs may interact with interferon beta-1a. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Rebif resources

• Rebif Side Effects (in more detail)
• Rebif Use in Pregnancy & Breastfeeding
• Rebif Drug Interactions
• Rebif Support Group
• 10 Reviews for Rebif - Add your own review/rating

• Rebif Prescribing Information (FDA)


• Rebif Advanced Consumer (Micromedex) - Includes Dosage Information


• Rebif MedFacts Consumer Leaflet (Wolters Kluwer)


• Rebif Consumer Overview


• Interferon Beta-1a Professional Patient Advice (Wolters Kluwer)


• Avonex Prefilled Syringes MedFacts Consumer Leaflet (Wolters Kluwer)


• Avonex Prescribing Information (FDA)


• Avonex Consumer Overview

Compare Rebif with other medications

• Multiple Sclerosis
• Neuritis

Where can I get more information?

• Your doctor or pharmacist can provide more information about interferon beta-1a.

See also: Rebif side effects (in more detail)